what Is Tacrolimus, Working Mechanism, Side Effects And Warnings?

What Is Tacrolimus?

Tacrolimus is a drug used after organ transplantation to prevent immune system rejection to the implanted organ,

such as in liver transplantation and kidney transplantation.

It is used to regulate the immune response of white blood cells, to treat autoimmune diseases, 

Tacrolimus is also used as a topical treatment in cases of skin infections.

This medicine is available in injection form as well



How does Tacrolimus work?

Now that you know what is Tacrolimus

let’s talk to you briefly about this drug

Tacrolimus inhibits the secretion of the calcineurin enzyme, which activates T cells that secrete lymphocytes that attack and expel any suspected substances.

Tacrolimus also acts as an anti-inflammatory drug for treating some skin conditions by inhibiting the secretion of the topical antimicrobial and prevents cells that secrete histamine.

Thus reducing the itchiness in the area with the inflammation.


What is Tacrolimus Exact Dosage?


For Children, Oral doses of 0.3 mg/kg are given every 12 hours.

– Or given intravenously at a dose of 0.05-0.15 mg / kg / day.

For adults, oral administration is given at a dose of 0.15-0.30 mg/kg daily at intervals of 12 hours, and intravenous injection is given three to four times the oral dose.

– Take the medicine before eating for an hour or an hour after eating ONLY.

– It is forbidden to crush or, chew or Tacrolimus tablets, just swallow it as a whole.

– As for the use of the drug as a contributor to skin infections, put a light layer of ointment on the affected area and rub in a nice way,
And avoid swimming or bathing after the ointment to continue to be effective, and the ointment should be removed from the area of the mouth and nose and eyes.

What Is Tacrolimus Contraindication?

– The use of this drug for patients with hypersensitivity to Tacrolimus substance.


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What Are Tacrolimus Interactions with Other Drugs:?


– The drug may interact with hormonal contraceptives, reducing their effect on the contraception, so the patient should follow some birth control methods other than hormonal means.

– The percentage of potassium in the blood may increase when using tacrolimus.

– If the level of tacrolimus increases in the blood, this may expose the patient to health risks if using any of these drugs:

macrolide, clarithromycin and erythromycin antibiotics, azulene antimicrobials such as ketoconazole and fluconazole

or when using reverse transcriptase inhibitors such as amprenavir, atazanavir and lopinavir, Calcium channels.

–  If the patient is taking phenobarbital, phenytoin, and rifampicin, The level of tacrolimus in the blood may decrease which decrease its effectiveness, Thus leading to the rejection of the implanted organ.



What Are The Tacrolimus Side Effects?

The patient who uses tacrolimus orally may experience some common side effects such as:

  • high blood pressure
  • headache
  • nausea
  • vomiting
  • diarrhea
  • renal function
  •  microbial infection


– In case of topical use of tacrolimus ointment on the skin, there also might be some side effects such as:

  • headache
  • tremor
  • fatigue
  • coughing
  • skin irritation
  • bacterial skin infection .



What Are The Warnings Before Using Tacrolimus?

– Avoid any crowded places, because tacrolimus weakens your immune system, which increases your ability to catch infections real easy.

– Inform your doctor if the patient is planning for pregnancy

– You should inform your doctor to take the necessary measures for patients with high blood pressure.


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-Extreme Caution and medical supervision is a Must when using tacrolimus by a lactating mother, because the drug is excreted in the milk and may adversely affect the baby.


-Avoid any sun exposure,as your skin will be very much exposed to develop skin burns easily.


What Is Tacrolimus Storage Method?

Store the medicine at room temperature away from heat and humidity

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